Knatchbull-Hugessen is a compound surname. Notable people with the name include:
Adrian Knatchbull-Hugessen (1891–1976), Canadian lawyer and senator Cecil Knatchbull-Hugessen, 4th Baron Brabourne (1863–1933), English cricketer and British peer Edward Knatchbull-Hugessen, 1st Baron Brabourne (1829–1893), British Liberal politician Edward Knatchbull-Hugessen, 2nd Baron Brabourne, (1857–1909), British peer and Liberal Party politician Eva Knatchbull-Hugessen, (1861–1895), English children's writer and social activist. Herbert Knatchbull-Hugessen (1835–1922), British Conservative politician Sir Hughe Knatchbull-Hugessen (1886–1971), British diplomat William Knatchbull-Hugessen (1837–1864), English cricketer Wyndham Knatchbull-Hugessen, 3rd Baron Brabourne (1885–1915), British peer and British Army officer
See also Knatchbull, surname James K. Hugessen (born 1933), judge serving on the Federal Court of Canada