Lifshitz (or Lifschitz) is a surname, which may be derived from the Polish city of Głubczyce (German: Leobschütz).

The surname has many variants, including: , , Lifshits, Lifshuts, Lifshutz, Lefschetz; Lipschitz (Lipshitz), Lipshits, Lipchitz, Lipschutz (Lipschütz), Lipshutz, Lipsitz, Lüpschütz; Libschitz; Livshits; Livshitz; Lifszyc, Lipszyc.

Notable people with the surname include:

Ada Yonath born Ada Esther Lifshitz (1939–2026), Israeli biochemist and Nobel laureate Asaf Lifshitz (1942–2025), Israeli sculptor Chava Lifshitz (1936–2005), Austrian-Israeli chemist Deborah Lifchitz or Lifszyc (1907–1942), Polish-French ethnologist and linguist Dovid Lifshitz (1906–1993), Suvalker Rav, taught at Yeshiva University Rabbi Eliezer Meir Lifshitz (1879–1946), for whom the Lifshitz College of Education was named Evgeny Lifshitz (1915–1985), Soviet physicist Ilya Lifshitz (1917–1982), Soviet physicist (brother of Evgeny) J. D. Lifshitz (born 1992), American film director May Simón Lifschitz (born 1995), actress and transgender model of Danish and Argentinian descent Miguel Lifschitz (1955–2021), Argentine politician, former mayor of the city of Rosario, Santa Fe Mikhail Lifshitz (1905–1983), Soviet literary critic and aesthetics philosopher Mosze Lifszyc (Aleksander Ford, 1908–1980), Polish film director Nechama Lifshitz (1927–2017), Soviet–Israeli singer Ofer Lifschitz (born 1958), chairman of Brit Olam party, Israel Ralph Lauren (born Ralph Lifshitz 1939), American fashion designer and business executive Sébastien Lifshitz (born 1968), French screenwriter and director Vladimir Lifschitz (born 1947), Soviet-American computer scientist Yaron Lifschitz (born 1970), Australian theatre director most notable for his involvement in the circus arts