M65 or M-65 may refer to:
Military Iveco LMV, an Italian-designed four-wheel drive tactical vehicle in service with several countries M65 atomic cannon, a towed artillery piece M65 Jacket, a multi-temperate jacket designed for the US Armed forces M65 recoilless nuclear rifle, a nuclear warhead for recoilless rifles Soltam M-65, an Israeli mortar Tikka M65, a Finnish rifle
Transportation M65 motorway, a motorway in England M-65 (Michigan highway), a Michigan state highway Miles M.65 Gemini, a 1945 British twin-engined four-seat touring aircraft M65 (Durban), a road in Durban, South Africa
Other uses Envelope, size with dimensions 110mm × 220mm Messier 65, a spiral galaxy in the constellation Leo M 65, an age group for Masters athletics (athletes aged 35+)