Neoschizomers are restriction enzymes that recognize the same nucleotide sequence, but cleave at different sites. The first restriction enzyme discovered to recognize a sequence is called the prototype, and others that recognize the same sequence are isoschizomers. Neoschizomers are a subset of isoschizomers.
For example, MaeII is the prototype enzyme for the sequence "ACGT", with the cleavage site A↓CGT. One of its neoschizomers, Tsp49I, also recognizes the sequence "ACGT", but cleaves at ACGT↓.
Another example is SmaI (CCC↓GGG), which is a neoschizomer of XmaI (C↓CCGGG).
Use in molecular biology
External links
Rebase restriction enzyme database, http://rebase.neb.com/rebase/
See also
Isoschizomer Isocaudomer List of restriction enzyme cutting sites
References
pl:Izoschizomery