12th Street may refer to:

Roads 12th Street (Chicago), now Roosevelt Road 12th Street (Erie, Pennsylvania) 12th Street (Manhattan) 12th Street (St. Louis) 12th Street (Washington, D.C.) Kingsway (Vancouver), which becomes 12th Street at its southeast end New Jersey Route 54, known locally as 12th Street

Transit 12th Street (GRTC BRT station) 12th Street station (DART), in Dallas, Texas, USA 12th Street/Jefferson and 12th Street/Washington stations, Valley Metro Rail stations in Phoenix, Arizona, USA 12th Street Oakland City Center station, a BART station in Oakland, California, USA

See also 12th Avenue (disambiguation)