Estrin is a surname. Notable people with the surname include:
Allen Estrin (born 1954), American screenwriter and co-founder of PragerU Dan Estrin (born 1976), guitarist for Hoobastank Deborah Estrin, American computer scientist Gerald Estrin (1921–2012), American computer scientist Judith Estrin, American business executive Marc Estrin (born 1939) American writer and political activist Morton Estrin (1923–2017), American pianist Robert Estrin (born 1942), American film editor Thelma Estrin (1924–2014), American computer scientist and biomedical engineer Yakov Estrin (1923–1987), Russian chess player
It may also refer to:
Estrin, a parent structure of the estrogen steroid hormones