St. Louis, Iron Mountain and Southern Railroad Depot may refer to
Any railroad station built by the St. Louis, Iron Mountain and Southern Railway
or specific notable ones (by state then city) Glenwood Iron Mountain Railroad Depot, Glenwood, AR, listed on the NRHP in Arkansas St. Louis, Iron Mountain and Southern Railroad Depot (Olyphant, Arkansas) St. Louis, Iron Mountain and Southern Railroad Depot (Fredericktown, Missouri), listed on the NRHP in Missouri St. Louis, Iron Mountain and Southern Railroad Depot (Gad's Hill, Missouri) St. Louis, Iron Mountain and Southern Railroad Depot (Jackson, Missouri) St. Louis, Iron Mountain and Southern Railroad Depot (Poplar Bluff, Missouri), listed on the NRHP in Missouri Sikeston St. Louis, Iron Mountain and Southern Railway Depot, Sikeston, MO, listed on the NRHP in Missouri