BOB, also known as 4-bromo-2,5,β-trimethoxyphenethylamine or as β-methoxy-2C-B, is a psychedelic drug of the phenethylamine, 2C, and BOx families. It is the β-methoxy derivative of 2C-B. BOB was first synthesized by Alexander Shulgin.

Use and effects In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists BOB's dose range as 10 to 20mg orally and its duration as 10 to 20hours. BOB Entry The effects of BOB have been reported to include closed-eye visuals, a sense of awareness, a rich altered place, paranoia, feeling sociopathic, feeling indifferent or emotionless, irritability, neurological overstimulation and instability, tiredness, turmoil, body tingling, and tinnitus.

Interactions

Pharmacology Pharmacodynamics BOB acts as a serotonin 5-HT2A receptor agonist. Its affinity (Ki) was found to be 2.0nM and its was 0.12nM with an 63%. Its affinity was 20-fold lower than that of DOB, its activational potency was half that of DOB and its efficacy was slightly higher than that of DOB (63% and 38%, respectively). 2C-B was said to have comparable affinity as DOB.

Chemistry Synthesis The chemical synthesis of BOB has been described.

Analogues Analogues of BOB include BOH-2C-B (BOHB; β-hydroxy-2C-B), βk-2C-B (β-keto-2C-B), BOD (β-methoxy-2C-D), BOHD (β-hydroxy-2C-D), and β-methyl-2C-B (BMB), among others.

History BOB was first described in the scientific literature by Alexander Shulgin, Peyton Jacob III, and Darrell Lemaire in 1985. Subsequently, it was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). The drug's pharmacology was studied by Richard Glennon and colleagues in 2004.

Society and culture Legal status Canada BOB is a controlled substance in Canada under phenethylamine blanket-ban language.

United Kingdom This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.

United States BOB is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also BOx (psychedelics) 2C (psychedelics)

References

External links BOB - Isomer Design BOB - PiHKAL - Isomer Design The Small & Handy BOX-Series Thread - Bluelight