Kuffour is a surname. Notable people with the surname include:
Bice Osei Kuffour (born 1981), Ghanaian hiplife musician Emmanuel Osei Kuffour (born 1976), Ghanaian footballer Isaac Kuffour (born 1978), Ghanaian footballer Jo Kuffour, (born 1981), English-born Ghanaian footballer Nana Kuffour (born 1985), Ghanaian-American soccer player Samuel Kuffour (born 1976), Ghanaian footballer