Cyclopropylmescaline

Cyclopropylmescaline (CPM), also known as 4-cyclopropylmethoxy-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline. It is taken orally and has a very long duration of 12 to 18hours.

Use and effects In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists CPM's dose as 60 to 80mg orally and its duration as 12 to 18hours. CPM Entry in PiHKAL Its onset is within 20minutes and peak effects occurred at around 1.5hours. The drug is approximately 5times as potent as mescaline and is longer-lasting in comparison.

The effects of CPM have been reported to include remarkable closed-eye visuals and fantasy, mental imagery synchronized with music, not much in terms of open-eye visuals, heightened tactile awareness, not much insight, daydreaming about eroticism, feeling exposed and vulnerable, sounds including voices and even music feeling intrusive and irritating, and interference with sleep and feeling tired due to its very long duration.

Interactions

Pharmacology Pharmacodynamics CPM acts as a serotonin 5-HT2 receptor full agonist, including of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.

Chemistry Synthesis The chemical synthesis of CPM has been described.

Analogues Analogues of CPM include mescaline, escaline, proscaline, allylescaline, methallylescaline, and cycloproscaline, among others.

History CPM was described in the scientific literature by Alexander Shulgin by 1994. Subsequently, it was further described by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).

Society and culture Legal status Canada CPM is not a controlled substance in Canada as of 2025.

Cyclopropylmescaline

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