CofC may refer to:
Children of the Confederacy, American lineage society Church of Christ, non-denominational Christian church influenced by the Restoration Movement Community of Christ, American-based international church, focused on peace and justice College of Charleston, public university located in Charleston, South Carolina Certificate of Conformity, Conformance or Compliance Certificate of Conformity 2-phospho-L-lactate guanylyltransferase, an enzyme
CoFC may refer to: United States Court of Federal Claims
COFC may refer to: "Container on Flatcar", a form of intermodal freight transport with intermodal containers Certificate of Formula Compliance Certificate of Formula Compliance Cherry Orchard F.C., an Irish football club Cookstown Olympic F.C., a Northern Irish football club