Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein. which have been renamed according to the different classes of POU domain. Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells. On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues. Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development. Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.
Human Oct proteins
Oct-1 - Oct-2 - Oct-3/4 – Oct-6 – Oct-7 – Oct-8 – Oct-9 – Oct-11 –
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