São Paio may refer to the following places in Portugal:
São Paio (Arcos de Valdevez), a parish in the municipality of Arcos de Valdevez São Paio (Gouveia), a parish in the municipality of Gouveia São Paio (Guimarães), a parish in the municipality of Guimarães São Paio (Melgaço), a parish in the municipality of Melgaço São Paio de Oleiros, a parish in the municipality of Santa Maria da Feira