William Prescott (1726–1795) was an American colonel in the Revolutionary War.
William Prescott may also refer to:
William Prescott Jr. (1762–1844), United States lawyer William Prescott (physician) (1788–1875), United States physician, politician, and naturalist William H. Prescott (1796–1859), American historian W. W. Prescott (William Warren Prescott, 1855–1944), Seventh-Day Adventist leader Sir William Prescott, 1st Baronet (1874–1945), British engineer and Conservative Party politician William Robert Stanley Prescott (1912–1962), Conservative Party politician in the United Kingdom William Prescott (Kansas politician) (born 1954), member of the Kansas House of Representatives Sir William Prescott, a steam engine, see Kempton Park Steam Engines