CFR may refer to:

Biology 23S rRNA (adenine2503-C2,C8)-dimethyltransferase, an enzyme 23S rRNA (adenine2503-C2)-methyltransferase, an enzyme

Organizations China Fire and Rescue, China's firefighting force , the Romanian state railway Canadian Finals Rodeo Centre for Foreign Relations, Tanzania CFR Cluj, Romanian football club CFFR, a Canadian radio station once branded as "66 CFR" Chess Federation of Russia, the governing body for chess in Russia Council on Foreign Relations, U.S. foreign policy think tank Franciscan Friars of the Renewal, a religious institute in the Catholic Church commonly abbreviated as "CFR"

Places Caen–Carpiquet Airport in northern France

Protocols Charter of Fundamental Rights, a charter of political, social and economic rights for European Union (EU) citizens Code of Federal Regulations of the United States

Titles Certified first responder Commander of the Order of the Federal Republic, Nigerian order of merit

Other Case fatality rate, term for proportion of people dying of a disease The Common Frame of Reference drafted for the development of a European civil code of law Compact fusion reactor, a proposed nuclear fusion reactor project Contact flight rules, an obsolete aviation term superseded by visual flight rules Coronary flow reserve, a diagnostic cardiac measurement Cost and Freight, word used in international commerce Cross-functional requirements, another name for non-functional requirements or the "ilities" in software systems requirements and design Chinese Folk Religion, the millennia-old indigenous beliefs and folklore of China that later morphed into Taoism, Confucianism, and Chinese Buddhism