S. Harris may refer to:
Sampson Willis Harris (1809-1857), American politician Sidney Harris (born 1933), American cartoonist Sadie Harris, fictional character from the television show Grey's Anatomy S. Harris, co-writer with Juan Tabo of the short story "If You Were an Award, My Love" Shyamala Gopalan, married as Shayamala Gopalan Harris
See also List of people with surname Harris