Dioscorus I (), also known as Dioscorus the Great, was the pope of Alexandria and patriarch of the See of St. Mark who was deposed by the Council of Chalcedon in 451. He was recognized as patriarch by the Coptic Church until his death. He died in Gangra, Paphlagonia, in September 454. He is venerated as a saint by the Coptic and other Oriental Orthodox Churches.

Early life Dioscorus' origins are unknown, although it is known that he was not a Copt. Dioscorus served as the dean of the Catechetical School of Alexandria, and was the personal secretary of Cyril of Alexandria, whom he accompanied to the Council of Ephesus in 431. He eventually rose to the position of archdeacon.Encyclopædia Britannica, Micropædia v. 4, p. 112. Chicago: Encyclopædia Britannica, Inc., 1998. . He had been made Cyril's designated successor.

Opposition to Nestorius In his struggle against Nestorius, Cyril explained the union between the divine and human natures of Christ as "inward and real without any division, change, or confusion." He rejected the Antiochene theory of "indwelling", or "conjunction" or "close participation", as insufficient. Thus the Alexandrian formula adopted by Cyril and Dioscorus was, in Greek, , which translates into "one nature of God the Word Incarnate", by which Cyril meant "one nature"—that Christ is at once God and man. On the other hand, the Antiochene formula was "two natures after the union", or "in two natures", which translates to . This formula explained Christ as existing in two natures, God and man.

Nestorius was condemned and deposed by the First Council of Ephesus, which approved of the Second Epistle of Cyril to Nestorius.

Patriarch of Alexandria Dioscorus succeeded Cyril as Patriarch of Alexandria in the summer of 444.

Soon after Dioscorus' consecration, Theodoret sent a letter (Letter 60) to him. In this letter he praises Dioscorus' modesty and humility, stating: "you do not behold the multitude of your subjects nor the exaltation of your throne, but you see rather human nature, and life's rapid changes, and follow the divine laws whose observance gives us the kingdom of heaven". Though being theologically opposed to him, Theodoret always positively represents Dioscorus' qualities. Theodoret had written against the 12 Anathemas of Saint Cyril and did not condemn Nestorius until the Council of Chalcedon. W. Bright states that Theodoret's: "testimony in his favour cannot be suspected".

Cyril's nephew Athanasius, who C. Haas describes as a "wealthy Alexandrian priest and potential rival" was a fierce critic of Dioscorus. Immediately after his accession Dioscorus was worried that the influential group of Cyril's relatives would be tempted to sabotage his tenure. He was also legally obliged to persecute them for misappropriating church property. Dioscorus regained property (including boats) for the Church, and destroyed property and fruit trees that had been illegally situated on land belonging to the Church. Athanasius claimed that from the outset of his episcopate, Dioscorus harassed him and his brother by using influence with the court, so that the brother died of distress, and Athanasius, with his aunts, sister-in-law, and nephews, were bereft of their homes by the patriarch's malignity. According to the deacon Ischyrion in the third session of the Council of Chalcedon in 451, Dioscorus had laid waste to property, inflicted fines and exile, as well as buying up and selling at a high price the wheat sent by the government to Libya. In Patriarch Dioscorus of Alexandria: The Last Pharaoh and Ecclesiastical Politics in the Later Roman Empire, V.L. Menze writes that illegal property had been "bearing income to the deacon Ischyrion".

Reception of Eutyches Eutyches was an archimandrite in Constantinople. In his opposition to Nestorianism, he seemed to take an equally extreme, although opposite view. Eutyches claimed to be a faithful follower of Cyril. In November 448, Flavian, Bishop of Constantinople held a synod regarding a point of discipline connected with the province of Sardis. Eutyches had been accusing various personages of covert Nestorianism, and at the end of the session of this synod one of those inculpated, Eusebius, Bishop of Dorylaeum, brought the question forward, and proffered a counter charge of heresy against the archimandrite. Eutyches was summoned to clarify his position regarding the nature of Christ. When asked whether Christ was in two natures after the union, Eutyches responded by stating: "I confess that our Lord was of two natures before the union, but after the union, one nature... I follow the teaching of the blessed Cyril and the holy Fathers and the holy Athanasius, because they speak of two natures before the union, but after the union and incarnation, they speak not of two natures but of one nature." Flavian had demanded that Eutyches confess two natures. Finding his response unsatisfactory, the synod condemned and exiled Eutyches as well as excommunicating anyone associated with him.

Eutyches appealed against this decision, labeling Flavian a Nestorian, and received the support of Dioscorus. In his famous Tome, Pope Leo I confirmed Flavian's theological position but as he concluded that Eutyches had erred through ignorance, he also requested that Eutyches should be readmitted if he repented.

Second Council of Ephesus Through the influence of the court official Chrysaphius, the godson of Eutyches, in 449, Emperor Theodosius II convened the Second Council of Ephesus. In remembrance of Cyril's role during the council of 431, the emperor asked Dioscorus to preside over the meetings. The council subsequently decided to reinstate Eutyches and to depose Flavian, as well as Eusebius of Dorylaeum, Theoderet of Cyrrus, Ibas of Edessa, and Domnus II of Antioch. Leo's legates protested but were ignored. Dioscorus and his council proceeded to depose Theodoret and several other bishops. Pope Leo called the council a "robber synod". In the spring of 450 at Nicaea, Dioscorus, while on his way to the court, caused ten bishops whom he had brought from Egypt to sign a document excommunicating Pope Leo. Flavian was sent into exile. Anatolius, who had been the agent of Dioscorus at Constantinople, was appointed his successor.

The common narrative is that Dioscorus partook in and/or ordered an assault on Flavian, who died three days later. However, there are varying accounts at the Council of Chalcedon in 451 of who killed Flavian. Those accused included Dioscorus himself (Session I, Line 30, and many other lines), his soldiers (Session I, Line 54), his personal clerics (Session III, 54), the Bishops of Egypt, Illyricum, and Palestine (Session I, Line 32, 38), Barsauma (Session IV, Line 77, 81), Barsauma's monks (Session I, Line 851), the Parabalani (Session I, Line 851), the Bishops who opposed Dioscorus (Session I, Line 853), a miscellaneous mob (Session I, Line 62, 851) and Juvenal of Jerusalem (Session I, Line 62). In The Exile and Death of Flavian of Constantinople: A Prologue to the Council of Chalcedon, H. Chadwick claims that Pulcheria and possibly Anatolius were most likely responsible because she planned "reunion with Rome" and a council that would overturn unfavourable results at the Second Council of Ephesus. Given they wanted to overturn the results of the council, he notes that Pope Leo I would never have been willing to recognise Anatolius as bishop if Flavian were still alive. Given Flavian was being exiled he would be incapable of pursuing their objectives. Chadwick states that: "Nothing could have been easier than to arrange an unfortunate 'accident'. Nothing would have been more convenient to Pulcheria and the patriarch than his removal from the scene." When Flavian is killed and Anatolius comes to power, Chadwick notes a "dramatic decision to throw Dioscorus aside, to reassert the claims of his see to be the second see of Christendom, and to accept, as a necessary bargain, the Tome of Leo." He sees these facts as indicating Flavian's death was ultimately in Pulcheria and Marcian's best interest.

Additional, possibly embellished details about Flavian's death only appear in later authors. The earliest source on Flavian's death, Nestorius, describes how Flavian was beaten at Ephesus, though not to death, and then banished to his home city of Hypaepa. However, the soldiers rushed him to his place of exile (with murderous intent, according to Nestorius), so that Flavian's injuries combined with the fatigue of the journey led to his death after four days. Prosper of Aquitaine, another contemporary, affirms that Flavian was killed by the soldiers taking him to his place of banishment. In a disputed letter to Theodoret dated 11 June 453, Pope Leo blamed Dioscorus in a general sense for Flavian's death. Liberatus of Carthage relates that Flavian suffered blows and died as a result. According to Evagrius Scholasticus, Eusebius of Dorylaeum complained at the council that Dioscorus himself, along with Barsauma's monks, beat and kicked Flavian. Theophanes the Confessor, writing three centuries after the event, mentions that Dioscorus personally struck Flavian "both with hands and feet". The detail of Flavian clutching the altar as he was beaten is also a later invention.

Theodosius supported the council's decisions until he died on 28 July 450. His sister Pulcheria returned to power and made the officer Marcian her consort and emperor. She consulted with Pope Leo on convoking a new council, gathering signatures for his Tome to be introduced as the basic paper for the new council, but also insisted, against Leo's wishes, that the council should be held not in Italy but in the East. Meanwhile, the new imperial couple brought Flavian's remains back to Constantinople and exiled Eutyches to Syria.

Council of Chalcedon

The Council of Chalcedon in October 451 dealt with the Christological views of Eutyches but also with Dioscorus' views and earlier behaviour; specifically, his condemnation of the bishop Flavian in Ephesus II was questioned. When, at the Council of Chalcedon, he was asked why he had deposed Flavian, he, according to the minutes of Chalcedon, responded, "Flavian was deposed for this reason, that he spoke of two natures after the union. But I have quotations from the holy fathers Athanasius, Gregory and Cyril saying in numerous places that one should not speak of two natures after the union".Richard Price & Michael Gaddis, The Acts of the Council of Chalcedon, vol. 1 (Liverpool University Press, 2005; ), p. 190

At the council, Dioscorus expressed a willingness to condemn Eutyches. According to the minutes of the council of Chalcedon, Dioscorus stated: "If Eutyches holds opinions contrary to the doctrines of the church, he deserves not only punishment but hell fire. For my concern is for the apostolic faith and not for any human being."