GTX may refer to:

Companies GTx Incorporated, an American pharmaceutical company

Transportation Mazda Familia GTX, a turbocharged automobile Plymouth GTX, an automobile produced 1967–1971 Sea-Doo GTX, a personal watercraft Great Train eXpress, an urban railway network Seoul, South Korea

Science and technology GeForce GTX, a brand of graphics processing units Global Trade Exchange, a United States Homeland Security intelligence project Gonyautoxin, several toxic molecules produced by algae GTX program, a 2002 NASA project for an air-augmented rocket

Other uses IMSA GTX, a sport car racing category

See also RTX (disambiguation)