GCU may refer to:

Education Georgian Court University, in Lakewood, New Jersey, United States Glasgow Caledonian University, in Scotland, United Kingdom Government College Umuahia, a secondary school in Nigeria Government College University (disambiguation) Grand Canyon University, in Phoenix, Arizona, United States Great Cities' Universities, an American research-sharing association

Other uses Alanine, an amino acid used in the biosynthesis of proteins which may be encoded by GCU General Contact Unit, a class of fictional artificially intelligent starship in The Culture universe of late Scottish author Iain Banks Greek Catholic Union of the USA, known as GCU