Safi al-Din () is an Arabic masculine given name and surname. It may also be spelled as Safi-ad-din, Safiuddin, Safieddine etc. The name is composed of two Arabic elements: Safi (صافي) meaning pure and Al-Din (الدین) religion. It may refer to:
Safi al-Din Abu Shnaaf (1931–2018), Egyptian military general Safi al-Din al-Hilli (1278–1349), Arab poet Safi al-Din al-Hindi (c. 1246–1315), Indian Islamic scholar Safi al-Din al-Urmawi (c. 1216 – 1294), Persian musician and writer Safi-ad-din Ardabili (1252–1334), Kurdish poet, Islamic mystic and eponym of the Safavid dynasty Safiuddin Ahmed (1922–2012), Bangladeshi painter Abdallah Safi-Al-Din (born 1960), Lebanese Hezbollah official and diplomat Francois Safieddine, American poker player Hashem Safieddine (1964–2024), Lebanese Shia cleric and Hezbollah leader
See also Safiuddin Sarker Academy and College, Bangladesh