NBC 22 may refer to one of the following television stations in the United States:
Current WLWK-CD in Sturgeon Bay, Wisconsin Translator of WGBA-TV in Green Bay, Wisconsin WWLP in Springfield, Massachusetts
Former KFSA-TV (now KFSM-TV on channel 5) in Fort Smith, Arkansas (1953 to 1958) WJCL in Savannah, Georgia (1982 to 1985) WKEF in Dayton, Ohio (1980 to 2004)