Route 215 or Highway 215 may refer to:
Argentina Buenos Aires Provincial Route 215
Canada Manitoba Provincial Road 215 New Brunswick Route 215 Nova Scotia Route 215 Prince Edward Island Route 215 Quebec Route 215
Chile Route 215-CH in Los Lagos Region
China China National Highway 215
Costa Rica National Route 215
Ireland R215 road (Ireland)
Germany Bundesautobahn 215 (A 215) Bundesstraße 215 (B 215)
India National Highway 215 (India)
United Kingdom road B215 road
United States Interstate 215 (California) Interstate 215 (Nevada) Interstate 215 (Utah) Alabama State Route 215 Arkansas Highway 215 California State Route 215 (former) Clark County 215 Florida State Road 215 (former) Georgia State Route 215 Iowa Highway 215 (former) K-215 (Kansas highway) Kentucky Route 215 Maine State Route 215 M-215 (Michigan highway) (former) Missouri Route 215 Montana Secondary Highway 215 New Mexico State Road 215 New York State Route 215 North Carolina Highway 215 Ohio State Route 215 Oregon Route 215 (former) Pennsylvania Route 215 South Carolina Highway 215 Tennessee State Route 215 Texas State Highway 215 (former) Texas State Highway Spur 215 Utah State Route 215 (former) Vermont Route 215 Virginia State Route 215 Washington State Route 215 Wyoming Highway 215