Onofrio is an Italian male given name and surname, derived from the saint Onuphrius. Notable people with the name include:
As a given name Onofrio Avellino (1674–1741), Italian painter Onofrio Barone (born 1964), Italian football coach and former player Onofrio Catacchio (born 1964), Italian comics artist Onofrio Fusco (1918–1994), Italian football player and manager Onofrio Gabrielli (1619–1706), Italian painter Onofrio del Grillo (1714-1787), Italian papal nobleman Onofrio Antonio Gisolfi (died 1656), Italian engineer and architect Onofrio Montesoro (1647–1722), Italian Roman Catholic prelate Onofrio Palumbo (1606–1650s), Italian painter Onofrio Panvinio (1529–1568), Italian Augustinian friar, historian and antiquary Onofrio de Ponte (died 1676), Italian Roman Catholic prelate Onofrio Puglisi (died 1679), Italian mathematician Onofrio di Santa Croce (died 1471), Italian Roman Catholic cardinal Onofrio Sciortino (died 1959), Italian-American mobster Francesco Onofrio Manfredini (1684–1762), Italian composer, violinist and church musician Francesco Onofrio Odierna (1644–1736), Italian Roman Catholic prelate Lorenzo Onofrio Colonna, multiple people
As a surname Al Onofrio (1921–2004), American football player and coach Judy Onofrio (born 1939), American artist Marco Onofrio (born 1971), Italian writer, essayist and literary critic Anna-Joséphine Dufour-Onofrio (1817–1901), French-Swiss businesswoman
See also D'Onofrio Onofri Sant'Onofrio (disambiguation)