Maria Cruz or Marie Cruz may refer to:
Maria de Lourdes Martins Cruz, East Timorese religious sister María Ruiz Cruz (born 1980), Spanish actress María Patricia Franco Cruz, Mexican politician María Carolina Santa Cruz, Argentine swimmer Sacheen Littlefeather (Marie Louise Cruz, 1946–2022), Native American activist Maria Elena Cruz, Arizona judge
See also Mari Cruz Díaz (born 1969), Spanish race walker María Cruz González (born 1971), Spanish field hockey player María de la Cruz (1912–1995), Chilean political activist