Samuel Gross may refer to:
Samuel D. Gross (1805–1884), pioneering American academic trauma physician Samuel Gross (Calder), an 1897 bronze statue by Alexander Stirling Calder Samuel Gross (politician) (1776–1839), American congressman from Pennsylvania Samuel R. Gross, American law professor Samuel Gross (Medal of Honor) (1891–1934), United States Marine Corps corporal and Medal of Honor recipient Sam Gross (born 1933), American cartoonist