Shupe may refer to:
Place names Shupe, Virginia, U.S. Shupe Peak, Victoria Land, Antarctica
People with the surname Anson Shupe (1948–2015), American sociologist Bryan Shupe, American politician Elisa Rae Shupe (1963-2025), American soldier Ryan Shupe, American musician Vince Shupe (1921–1962), Major League Baseball first baseman
Fictional characters Glen Shupe, an Irish drug addict featuring in the HBO television series Oz