Route 375 or Highway 375 may refer to:
Canada Manitoba Provincial Road 375 New Brunswick Route 375 Saskatchewan Highway 375
Japan Japan National Route 375
United States Interstate 375 Arkansas Highway 375 Florida State Road 375 Georgia State Route 375 (former) Maryland Route 375 (unsigned) Nevada State Route 375 New York State Route 375 Puerto Rico Highway 375 Texas State Highway Loop 375 Virginia State Route 375 Wyoming Highway 375