Pelosi () is an Italian surname meaning 'hairy' (masculine plural).

As a surname, Pelosi may refer to the following people:

Alexandra Pelosi (born 1970), American journalist, documentary filmmaker, writer, and daughter of Nancy Pelosi Christine Pelosi (born 1966), American political strategist and daughter of Nancy Pelosi Claudio Pelosi (born 1966), Italian football striker Daniel Pelosi (born 1963), American convicted murderer John Pelosi (born 1956), Scottish football right winger Marc Pelosi (born 1994), American soccer midfielder Nancy Pelosi (born 1940), the 52nd speaker of the United States House of Representatives Paul Pelosi (born 1940), American businessman, sports executive, and husband of Nancy Pelosi Roberta Pelosi (born 1960), Italian sport shooter Ron Pelosi (born 1934), American politician and brother-in-law to Nancy Pelosi Salvatore Pelosi (1906–1974), Italian Naval officer who fought in World War II