Signaling peptide receptor

Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins.

An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin.

Adiponectin receptor

AdipoR1

Agonists Peptide Adiponectin ADP-355 ADP-399 Non-peptide AdipoRon (–)-Arctigenin Arctiin Gramine Matairesinol Antagonists Peptide ADP-400

AdipoR2

Agonists Peptide Adiponectin ADP-355 ADP-399 Non-peptide AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol Antagonists Peptide ADP-400

Angiotensin receptor

Bradykinin receptor

Agonists Bradykinin Kallidin Antagonists FR-173657 Icatibant LF22-0542

Calcitonin gene-related peptide receptor

Agonists Amylin CGRP Pramlintide Antagonists Atogepant BI 44370 TA CGRP (8-37) MK-3207 Olcegepant Rimegepant SB-268262 Telcagepant Ubrogepant Antibodies Eptinezumab Erenumab Fremanezumab Galcanezumab

Cholecystokinin receptor

CCKA

Agonists Cholecystokinin Antagonists Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide

CCKB

Agonists Cholecystokinin CCK-4 Gastrin Pentagastrin (CCK-5) Antagonists Ceclazepide CI-988 (PD-134308) Itriglumide L-365,360 Netazepide Proglumide Spiroglumide

Unsorted Antagonists Nastorazepide

Corticotropin-releasing hormone receptor

CRF1

Agonists Cortagine Corticorelin Corticotropin-releasing hormone Sauvagine Stressin I Urocortin Antagonists Antalarmin Astressin-B CP-154,526 Emicerfont Hypericin LWH-234 NBI-27914 NBI-74788 Pexacerfont R-121919 TS-041 Verucerfont

CRF2

Agonists Corticorelin Corticotropin-releasing hormone Sauvagine Urocortin Antagonists Astressin-B

Cytokine receptor

Endothelin receptor

Agonists Endothelin 1 Endothelin 2 Endothelin 3 IRL-1620 Sarafotoxin Antagonists A-192621 Ambrisentan Aprocitentan Atrasentan Avosentan Bosentan BQ-123 BQ-788 Clazosentan Darusentan Edonentan Enrasentan Fandosentan Feloprentan Macitentan Nebentan Sitaxentan Sparsentan Tezosentan Zibotentan

Galanin receptor

GAL1

Agonists Galanin Galanin (1-15) Galanin-like peptide Galmic Galnon NAX 810-2 Antagonists C7 Dithiepine-1,1,4,4-tetroxide Galantide (M15) M32 M35 M40 SCH-202596

GAL2

Agonists Galanin Galanin (1-15) Galanin (2-11) Galanin-like peptide Galmic Galnon J18 NAX 810-2 Antagonists C7 Galantide (M15) M32 M35 M40 M871

GAL3

Agonists Galanin Galanin (1-15) Galmic Galnon Antagonists C7 Galantide (M15) GalR3ant HT-2157 M32 M35 M40 SNAP-37889 SNAP-398299

Growth hormone secretagogue receptor

Growth hormone receptor

Growth-hormone-releasing hormone receptor

Glucagon-like peptide receptor

GLP-1

Agonists Albiglutide Beinaglutide Dulaglutide Efpeglenatide Exenatide GLP-1 Langlenatide Liraglutide Lixisenatide Oxyntomodulin Pegapamodutide Semaglutide Taspoglutide

GLP-2

Agonists Apraglutide Elsiglutide Glepaglutide GLP-2 Teduglutide

Others Propeptides Preproglucagon Proglucagon

Glucagon receptor

Agonists Dasiglucagon Glucagon Oxyntomodulin Antagonists Adomeglivant L-168,049 LGD-6972 Propeptides Preproglucagon Proglucagon

Gonadotropin-releasing hormone receptor

Gonadotropin receptor

Growth factor receptor

Insulin receptor

Agonists Chaetochromin (4548-G05) Insulin-like growth factor 1 Insulin-like growth factor 2 Insulin Insulin aspart Insulin degludec Insulin detemir Insulin glargine Insulin glulisine Insulin lispro Mecasermin Mecasermin rinfabate Antagonists BMS-754807 S661 S961 Kinase inhibitors Linsitinib Antibodies Xentuzumab (against IGF-1 and IGF-2)

KiSS1-derived peptide receptor

Agonists Kisspeptin (kisspeptin-54, metastin) Kisspeptin-10 KISS1-305 MVT-602 (RVT-602, TAK-448) TAK-683 Antagonists Kisspeptin-234

Leptin receptor

Agonists Leptin Metreleptin

Melanin-concentrating hormone receptor

MCH1

Agonists Melanin-concentrating hormone Antagonists ATC-0065 ATC-0175 GW-803430 NGD-4715 SNAP-7941 SNAP-94847

MCH2

Agonists Melanin-concentrating hormone

Melanocortin receptor

Neuropeptide FF receptor

Agonists Neuropeptide AF Neuropeptide FF Neuropeptide SF (RFRP-1) Neuropeptide VF (RFRP-3) Antagonists BIBP-3226 RF9

Neuropeptide S receptor

Agonists Neuropeptide S Antagonists ML-154 SHA-68

Neuropeptide Y receptor

Y1

Agonists Neuropeptide Y Peptide YY Antagonists BIBO-3304 BIBP-3226 BVD-10 GR-231118 PD-160170

Y2

Agonists 2-Thiouridine 5'-triphosphate Neuropeptide Y Neuropeptide Y (13-36) Peptide YY Peptide YY (3-36) Antagonists BIIE-0246 JNJ-5207787 SF-11

Y4 Agonists GR-231118 Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists UR-AK49

Y5

Agonists BWX-46 Neuropeptide Y Peptide YY Antagonists CGP-71683 FMS-586 L-152,804 Lu AA-33810 MK-0557 NTNCB Velneperit (S-2367)

Neurotensin receptor

NTS1

Agonists Neurotensin Neuromedin N Antagonists Meclinertant SR-142948

NTS2

Agonists Neurotensin Antagonists Levocabastine SR-142948

Opioid receptor

Orexin receptor

Oxytocin receptor

Prolactin receptor

Parathyroid hormone receptor

Agonists Abaloparatide Parathyroid hormone Parathyroid hormone-related protein (PTHrP) Semparatide Teriparatide

Relaxin receptor

Agonists Insulin-like factor 3 Relaxin (1, 2, 3) Serelaxin

Somatostatin receptor

Tachykinin receptor

Thyrotropin-releasing hormone receptor

Agonists Azetirelin JTP-2942 Montirelin Orotirelin Posatirelin Protirelin Rovatirelin RX-77368 (thymoliberin) Taltirelin TRH (TRF)

Thyrotropin receptor

Agonists Thyrotropin alfa TSH (thyrotropin)

Vasopressin receptor

Vasoactive intestinal peptide receptor and Pituitary adenylate cyclase-activating peptide

VIPR1

Agonists Peptide Bay 55-9837 LBT-3393 PACAP VIP

VIPR2

Agonists Peptide LBT-3627 PACAP VIP

PAC1

Agonists PACAP PACAP (1-27) PACAP (1-38) Antagonists PACAP (6-38)

Unsorted PHI PHM PHV

Others Endogenous Adrenomedullin Apelin Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands collagens fibrinogen fibronectin laminins ICAM-1 ICAM-2 osteopontin VCAM-1 vitronectin Kininogens Motilin Natriuretic peptides ANP BNP CNP urodilatin Nesfatin-1 Neuromedin B Neuromedin N Neuromedin S Neuromedin U Obestatin Osteocalcin Resistin Secretin Thymopoietin Thymosins Thymulin Urotensin-II VGF Exogenous Lifitegrast (LFA-1 antagonist)

See also Neuropeptide receptor Neurotransmitter receptor

References

External links