The acronym SCLS can refer to several things:

In Medicine: Capillary leak syndrome a rare medical condition where the number and size of the pores in the capillaries are increased which leads to a leakage of fluid from the blood to the interstitial fluid, resulting in dangerously low blood pressure hypotension, edema and multiple organ failure due to limited perfusion In Education: The South Central Library System a consortium spanning 53 Public Libraries in South Central Wisconsin. In United States Law: Service Contract Labor Standards is a set of labor law regulations for companies receiving federal contracts; see McNamara–O'Hara Service Contract Act.