Joseph O'Brien may refer to:
Joseph Patrick O'Brien (born 1993), Irish jockey and racehorse trainer Joseph O'Brien (singer), American singer and songwriter Joseph C. O'Brien (born 1965), mayor of Worcester, Massachusetts, USA Joseph J. O'Brien (1897–1953), U.S. congressman from New York Joseph Leonard O'Brien (1895–1973), lieutenant governor of New Brunswick Joseph O'Brien (rower), Australian rower Joe O'Brien (basketball) (born 1955), basketball player Joe O'Brien (footballer) (1875 – after 1906), Scottish football full back Joey O'Brien (born 1986), Irish international and former Bolton Wanderers footballer Joey Aiuppa (1907–1997), American mobster whose nicknames include "Joey O'Brien"