James Duffy may refer to:

Sportsmen James E. Duffy (American football) (1867–1953), American football player and lawyer Jimmy Duffy (1890–1915), Canadian Olympian and winner of the 1914 Boston Marathon Jim Duffy (rugby league) (active 1915–1920), rugby league footballer James F. Duffy (1892–1961), American football coach Jim Duffy (umpire) (1920–2003), American baseball umpire Jim Duffy (footballer) (born 1959), Scottish football player and manager with Morton and Dundee Jim Duffy (baseball coach) (born 1974), American college baseball coach Jamie Duffy (born 1983), Irish footballer in 2007 FAI Cup, 2008 Dundalk F.C. season and 2008 Dundalk F.C. season James Duffy, English cricketer in MCC University matches in 2005

Others James Terence Duffy (1889-1939), American comedy performer James E. Duffy Jr. (born 1942), retired associate justice of the Hawaii State Supreme Court James Duffy (Irish publisher) (1809–1871), Irish publisher of Nationalist and Roman Catholic books, bibles and religious texts James Duffy (VC) (1889–1969), Irish recipient of the Victoria Cross James Duffy, a character in the short story "A Painful Case" (part of the book Dubliners) by James Joyce James Albert Duffy (died 1968), first bishop for the Diocese of Grand Island James P. B. Duffy (1878–1969), U.S. congressman from New York Jim Duffy (journalist) (born 1966), Irish historian and political commentator Jim Duffy (animator) (1937–2012), American animator Jim Duffey (1950–2019), Virginia secretary of technology Jamie Duffy (American musician) Jamie Duffy (Irish musician)