OSF may refer to:
Computing Open Science Framework, a cloud-based management for open access science Open Semantic Framework, an integrated software stack using semantic technologies for knowledge management OSF/1, a Unix-like operating system developed by the Open Software Foundation Opera Show Format, an XHTML-based slideshow format
Organisations Ógra Shinn Féin, the youth wing of the Sinn Féin political party Open Software Foundation, a not-for-profit organization that merged with X/Open and then became The Open Group Open Society Foundations, a grantmaking body established by George Soros OpenStack Foundation, a non-profit corporate entity to promote OpenStack software and its community Operational Support Facility, of the Federal Aviation Administration Oregon Shakespeare Festival, a repertory theatre in Ashland, Oregon, US Oxford Scientific Films, a British producer of natural history and documentary programmes The Old Spaghetti Factory, a restaurant chain Independent Senate Fraction (Onafhankelijke Senaatsfractie), a political group of the Netherlands Order of Saint Francis, a 21st-century American Franciscan religious order; see Oklahoma Office of State Finance, an agency of the Government of Oklahoma, US OSF Global Services, a cloud technology company OSF Healthcare, a non-profit healthcare organization in Illinois and Michigan, US