N4-(beta-N-acetylglucosaminyl)-L-asparaginase (, aspartylglucosylamine deaspartylase, aspartylglucosylaminase, aspartylglucosaminidase, aspartylglycosylamine amidohydrolase, N-aspartyl-beta-glucosaminidase, glucosylamidase, beta-aspartylglucosylamine amidohydrolase, 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase) is an enzyme with systematic name N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase. It catalyses the following chemical reaction
The enzyme characterised from mammalian kidney and hen oviduct hydrolyses aspartylglucosamine to N-acetyl-β-D-glucosaminylamine and aspartic acid. It acts only on asparagine-oligosaccharides containing one amino acid, the final step in glycoprotein degradation.
See also Aspartylglucosaminidase, the human variant of β-aspartyl-N-acetylglucosaminidase β-aspartyl-N-acetylglucosaminidase, which hydrolyses aspartylglucosamine to N-acetyl-D-glucosamine and L-asparagine
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