SPB may refer to:
Places Saint Petersburg, Russia Saint Paul's Bay, Malta South Park Blocks, a public park in Portland, Oregon
Science and technology Shortest Path Bridging in the IEEE 802.1aq standard Slowly pulsating B star, a type of variable star Spindle pole body, the functional equivalent of the mammalian centriole in yeast Superpressure balloon
Transportation Scappoose Industrial Airpark, Oregon, USA, FAA LID Schynige Platte Bahn, a mountain railway in Switzerland Charlotte Amalie Harbor Seaplane Base, U.S. Virgin Islands, IATA airport code SPB Shepherd's Bush railway station, London, National Rail station code SPB
Other uses Society of the Precious Blood, Anglican religious order Socialist Party of Bangladesh, Political party in Bangladesh S. P. Balasubrahmanyam (1946–2020), Indian playback singer, actor, music director, voice actor and film producer SPB Software, mobile software developer Belarus Free Trade Union, a trade union in Belarus State Procurement Board in South Australia Sparisjóðabanki, also known as SPB hf., a defunct bank in Iceland SPB TV, a company