ACDF may refer to:
Anterior cervical discectomy and fusion, a common surgical procedure Archive of the Congregation for the Doctrine of the Faith, the Catholic Church's documents dealing with doctrinal and theological issues related to church teaching Aeronautique Club de France, a French flying club based on Meaux-Esbly airfield, France, and created in 1897 Uzbekistan Art and Culture Development Foundation, a state‑backed cultural organisation in the Republic of Uzbekistan