Negron or Negrón is a Spanish language surname, and may refer to:
Alondra Negron (born 1998), Puerto Rican middle-distance runner Angélica Negrón (born 1981), Puerto-Rican composer and multi-instrumentalist Antonio Negrón García (1940–2025), Puerto Rican jurist, associate justice of the Supreme Court (1974–2000) Carlos Negrón (born 1988), Puerto Rican boxer Carlos Negron (wrestler) (born 1964), Puerto Rican wrestler Chuck Negron (1942–2026), American singer-songwriter Edna Negron Rosario (born 1944), American educator Esmeralda Negron (born 1983), American-born Puerto Rican footballer and coach Frances Negrón-Muntaner (born 1966), Puerto Rican filmmaker, writer, and scholar Frankie Negrón (born 1977), singer of salsa music and songwriter of Puerto Rican descent Jaqueline Negron (born 1989), singer of Puerto Rican descent Joe Negron (born 1961), member of the Florida House of Representatives Kristopher Negrón (born 1986), American baseball player Laudiel Negrón (born 1952), Puerto Rican boxer Luis Negrón (born 1970), Puerto Rican writer Mercedes Negrón Muñoz (1895–1973), Puerto Rican poet and essayist Priscilla Negrón (born 1984), Ecuadorian actress Taylor Negron (1957–2015), American stand-up comedian, actor, and artist Wilfredo Negrón (born 1973), Puerto Rican boxer