HFB may refer to:
Hafnium boride (HfB) Hamburger Flugzeugbau, German aircraft manufacturer Harry F. Byrd, a prominent US Senator from Virginia Hexafluorobenzene, an aromatic organofluoride Hexafluoro-2-butyne, an alkyne organofluoride Hindu Forum of Britain Hochschule für Bankwirtschaft (HfB), now part of the Frankfurt School of Finance & Management Housing Finance Bank, Uganda Houston Food Bank