The 1817 Santiago del Estero earthquake took place in the province of Santiago del Estero, Argentina, on 4 July at about 05:30p.m. It was estimated to be 7.0 on the Richter scale. Its epicenter was at , at a depth of 30 km.

The earthquake was felt with grade VIII on the Mercalli intensity scale in the provincial capital Santiago del Estero, where it caused grave damage.

References Instituto Nacional de Prevención Sísmica. Listado de Terremotos Históricos.