Point of origin may refer to:
Point of Origin (film), a 2002 biographical crime film Point of Origin (novel), a crime fiction novel by Patricia Cornwell "Point of Origin", an episode of season 5 of the US medical drama ER "Point of Origin" (The Inside episode) Point of Origin (There for Tomorrow album), 2004 Point of Origin (Person of Interest), 2014 "Point of Origin" (The Twilight Zone), 2019 episode of the television series The Twilight Zone Coordinate origin for a coordinate system
See also Points of Origin, 2025 album by Will Stratton Origin (disambiguation)