M57 or M-57 may refer to:

Transport M-57 (Michigan highway), a state highway in Michigan M57 motorway, a motorway in England M57 (Cape Town), a Metropolitan Route in Cape Town, South Africa M57 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa M57, a New York City Bus route in Manhattan

Weapons M57, variant of the MGM-140 ATACMS missile Halcón ML-57, an Argentine submachine gun TT pistol (Yugoslavian m57), a Yugoslavian-produced TT-33 pistol model, with an added safety Zastava M57, pistol M57 mortar, Yugoslavian 60mm Mortar

Other BMW M57, a 1998 diesel automobile engine Miles M.57 Aerovan, a 1945 British short-range, low-cost transport Messier 57 (M57), a planetary nebula also known as the Ring Nebula Rangeley Lake Seaplane Base (FAA LID: M57)