James Vaughan may refer to:
James Vaughan (priest), Dean of Achonry, Ireland, from 1662 to 1683 James Vaughan (magistrate) (1814-1906), British magistrate James David Vaughan (1864–1941), American musician James Churchill Vaughan (1893–1937), Nigerian physician James H. Vaughan (1934–1996), Canadian politician James J. Vaughan (1870–1935), American composer James Vaughan (footballer, born 1986), English right-back James Vaughan (footballer, born 1988), English former footballer James Vaughan (police officer), chief constable of Dorset Police James Vaughan, creator of the video game Plague Inc.
See also James Vaughn (disambiguation) Jim Vaughan (1868-?}, Welsh footballer Jimmie Vaughan (born 1951), American musician