The following is a list of Sites of Special Scientific Interest in the Tweeddale and Ettrick and Lauderdale Area of Search. For other areas, see List of SSSIs by Area of Search.

Airhouse Wood Akermoor Loch Ashkirk Loch Auchencorth Moss Avenel Hill and Gorge Bemersyde Moss Blind Moss Catshawhill Clarilaw Grasslands Colmsliehill Junipers Craigdilly Craigengar Dolphinton - West Linton Fens and Grassland Dunhog Moss Faldonside Loch Gattonside Moss Glenkinnon Burn Gordon Moss Grieston Quarry Henderland Bank Hermanlaw and Muckra Cleuchs Kingside Loch Kirkhope Linns Lammer Law Lindean Reservoir Lynslie Burn Makerstoun - Corbie Craigs to Trows' Craigs Moffat Hills Moorfoot Hills Mount Bog Newhall Glen Newtown St Boswells Woods North Esk Valley Nut Wood Plora Wood Riskinhope River Tweed Selkirk Racecourse Moss St Mary's Loch Thornylee Quarry Threepwood Moss Tweedsmuir Hills Tweedwood - Gateheugh Westwater Reservoir Whim Bog Whitlaw Mosses Whitlaw Rig Whitmuirhall Loch Williamhope Windy Gowl/Carlops Dean