The term EM2 may refer to:
Science and technology Energy Multiplier Module, a nuclear fission reactor under development by General Atomics Exploration Mission-2, a previous name of Artemis II, a planned mission for NASA's Orion spacecraft Expression Media 2, Microsoft digital asset management software, a precursor of Phase One Media Pro Haplogroup E-M2, an African haplogroup in human DNA EM2, a designation for a vacuum tube, of Magic Eye type
Transport British Rail Class 77, or Class EM2, an electric locomotive used on the Woodhead electrified railway line Embraer EMB 120 Brasilia, abbreviated EM2, a commercial aircraft manufactured in Brazil Elias EM-2, a 1920s US military biplane Freightliner eM2, an all-electric medium-duty cube truck EM2, chassis code for a 2001–2005 Honda Civic coupe EM-2, a model of farm tractor by the Greek company Malkotsis
Other EM-2 rifle, an experimental British assault rifle Epic Mickey 2: The Power of Two, a video game EM2, or Electrician's Mate 2nd Class, an enlisted rate in the US Navy and US Coast Guard EM2, a category for streaming pupils formerly used in education in Singapore