Acácio is both a masculine Portuguese given name and a surname. Notable people with the name include:
People with the given name Acácio Barreiros (1943–2004), Portuguese politician Acácio Casimiro (born 1949), Portuguese footballer Acácio (footballer) (Acácio Cordeiro Barreto, born 1959), Brazilian footballer and manager Acácio da Silva (born 1961), Portuguese cyclist Acácio de Almeida (born 1938), Portuguese cinematographer Acacio Mañé Ela (–1959), Equatoguinean nationalist and politician Acácio Mesquita (1909–1945), Portuguese footballer Acácio Pereira Magro (1932–2018), Portuguese academic, economist and politician Acácio Rodrigues Alves (1925–2010), Brazilian Roman Catholic bishop
People with the surname Adrião Acácio da Silveira Pinto (died 1868), Governor of Macau Daniel Acácio (born 1977), Brazilian mixed martial artist Marlon Acácio (born 1982), Mozambican judoka