Neighborhoods in Spokane, Washington are officially grouped by the Spokane City Council into three main city council districts: 1, 2, and 3. Each city council district contains multiple, official neighborhoods that are recognized with a neighborhood council. Informally, neighborhoods are colloquially grouped by local geographical, geological, cultural, or historical features (such as South Hill, North Side, Five Mile, Hillyard, South Perry, etc.) The list of neighborhoods below is organized based on the official designations by the City of Spokane. Unofficial neighborhoods and districts are listed within the official neighborhood in which they are located.

Neighborhoods in Spokane range from the late Victorian-era to the contemporary. With major peopling coming from the city's origins as a major rail center in the early 20th century, before the automobile, this has had an indelible impact on the urban form and character of Spokane and its neighborhoods. As the primary mode of transport was rail during its intensive growth phase, Spokane's first neighborhoods were dense streetcar suburbs, neighborhoods outside the hectic downtown where real estate companies developed transit-oriented housing where the interurbans were integral to their convenience and value. Much of Spokane city proper consists of traditionally planned neighborhoods with gridded streets that meet at straight, right angles that are well suited to efficient rail transit and often included a neighborhood shopping center on the block for residents. Spokane's interurban lines extended from Francis Avenue in the north to 38th Avenue on the South Hill. Beyond the former streetcar suburbs lie typical post World War II Suburban developments that consist mostly of single family housing.

District 1 (Northeast) The northeast side of Spokane extends roughly north from Downtown Spokane into the suburban Mead area. It is bounded on the west by Division St., the city's north–south meridian, and is bounded on the south by Interstate 90. The northeast side is mostly residential, but contains several large retail districts as well as Gonzaga and Whitworth Universities. Retail centers such as the Northtown Mall and Northpointe Plaza lie along Division Street.

Bemiss

Chief Garry Park

Named for Spokane Garry, it is a long neighborhood stretching for more than four miles from near the city center at Trent Avenue where it crosses the Spokane River northeast to Felts Field. Home to Spokane Community College.

Hillyard

Originally a city in its own right, it was later incorporated into the Spokane city limits. Downtown Hillyard, which runs along Market Street, is listed on the National Register of Historic Places as a historic district. Hillyard was named in honor of the Great Northern Railway magnate, James J. Hill. It is the poorest section of Spokane per capita.

Logan

The Logan Neighborhood comprises the residential area just north of Gonzaga University in central Spokane. University students occupy many of the neighborhood's homes.

University District

There are two campuses northeast of downtown, Gonzaga University, and the Riverpoint Campus, which contains branches of Washington State and Eastern Washington Universities, as well as an extension of the University of Washington medical school. A new university, Great Northern University, is also located here, with most students living in homes throughout the Logan Neighborhood. Plans call for increases in the student population in coming years, as well as additional housing, services, and entertainment geared toward a young, professional audience. Significant renewal and renovation, primarily of professional and medical business, is occurring in the area east of Division, west of Hamilton and north of the I-90 freeway.

Minnehaha

Located along Upriver Drive on the north bank of the Spokane River about east of downtown Spokane, the area is known for the granite climbing rocks and hiking/biking trails of John H. Shields Park. The Centennial bike trail, and a series of small parks and swimming holes along the river make this a popular getaway for city residents. Homes tend to be older along the river, with some newer subdivisions appearing on the terraces and slopes above.

Nevada Heights

Nevada Heights was established in 2016 when the Nevada/Lidgerwood neighborhood was split at Francis Avenue. The neighborhood encompasses the south half of its predecessor neighborhood. This neighborhood in Northeast Spokane is home to Northtown Mall, which at one time was the largest mall west of the Mississippi. Many houses in this neighborhood were built in the mid-1970s, although new home construction is also common. Whitman Elementary School, Garry Junior High School and John R. Rogers High School are all located within the Nevada Heights neighborhood.

Shiloh Hills

This neighborhood was established in 2016 when the Nevada/Lidgerwood neighborhood was split at Francis Avenue. Shiloh Hills encompasses the north half of its predecessor neighborhood.

Whitman

District 1 & 2 (Northeast and South) East Central

This neighborhood was bisected when Interstate 90 came through decades ago, and it is still recovering. The area sits at the foot of the South Hill, east of Downtown along the freeway. With plans for feeder lanes to be added to I-90, there will likely be further impact upon the neighborhood. What remains of the residential integrity of the area lies to the south of I-90, mostly in an area known as Liberty Park. The area north of the freeway and east of Hamilton has had little renewal since its original development in the early 20th century.

South Perry

Like much of Spokane, this street district turned de facto neighborhood dates back to the late 19th century. In the old days, it had two lumberyards, a butcher shop, barber shop, library, ice cream parlor, bakery, steam cleaner and several grocery stores. Today the South Perry Business District is undergoing something of a gentrification-fueled renaissance. Trendy restaurants, bars, shops and cafes have taken over many of the storefronts along Perry Street. Being located just to the southeast of the city center, South Perry was settled in the early days of Spokane and as a result is home to a good bit of history. Grant Elementary has been operating since 1900, though the original building no longer stands. The adjacent Grant Park was established in 1908. One of Spokane's oldest religious congregations, the Liberty Park Methodist Church, has kept its doors open since 1912. Sonora Smart Dodd, regarded as the founder of Father's Day, resided in the neighborhood with her husband. Their Dodd House, built in 1913, is listed on the Spokane Historic Register, the Washington State Heritage Register, and the National Register of Historic Places as a National Landmark. Some of the buildings in the business district date back from the early 1920s, and feature some fine examples of local granite stonework, and decorative shingles. There is even a Dutch windmill, a landmark in the area.City of Spokane – City Government The Spokane Buddhist Temple is located in South Perry.

District 2 (South) The south side of Spokane is largely characterized as Downtown, as well as Browne's Addition and the South Hill, which are home to Spokane's oldest residential areas. Geographically, the "hill" that forms the area encompasses the whole of the city proper south of downtown, from east to west and is characterized by highly variable terrain from block to block. From Downtown, the view of the South Hill is dominated by evergreen trees and two large man-made features: Sacred Heart Medical Center, which is Spokane's largest hospital, and the Cathedral of St. John the Evangelist, seat of the Episcopal Diocese of Spokane, and a magnificent example of modern English Gothic architecture.

Browne's Addition

A National Historic District west of Downtown, Browne's Addition was Spokane's first prestigious address, notable for its old mansions built in Queen Anne and early Craftsman styles, by Spokane's early elite. The area also is home to Coeur d'Alene Park and the Museum of Arts and Culture (MAC). A prominent feature of the MAC is the Campbell House, a turn-of-the-20th-century mansion designed by renowned architect Kirtland Cutter, and built by Amasa Campbell, a local mining magnate. His daughter, Helen Campbell, donated the house to the Eastern Washington Historical Society, which subsequently built a museum on the east lawn. The English Tudor Revival home retains most of its original decor and is a favorite tour destination.

Cliff/Cannon

Bounded on the north by Interstate 90, this neighborhood lies between Third and Fourth avenues. In the far northern portion are Sacred Heart Medical Center and Deaconess Hospital, which anchor Spokane's medical district. Sitting between the two hospitals is the historic Lewis and Clark High School. This portion of Cliff/Cannon is separated from the rest of the neighborhood by a steep hill., which in places is a sheer cliff of exposed basalt. Unofficially this hill marks the beginning of the multi-neighborhood region of Spokane known as the South Hill, the transition from the city center to residential areas south side of the city. On the western edge of Cliff/Cannon is another steep hill, this one carved by Latah Creek. The BNSF Railway and Inland Empire Way divide the Latah Valley neighborhood from Cliff/Cannon and the South Hill.

Cannon's Addition

Cannon's Addition was named for and originally platted by Anthony McCue Cannon. The need for housing was great after the Fire of 1889 and many architects moved to Spokane to take advantage of the rapid growth. The primary development of Cannon's Addition occurred between 1900 and 1925. The first streets that were developed included Third, Fourth and Fifth Avenue. The northern portion of Cannon's Addition, located closest to the city's downtown core, quickly evolved into an area where the houses of prominent Spokane citizens were constructed. In the original 1883 platting of Cannon's Addition, the streets only went as far south as Tenth; Eleventh, Twelfth, Thirteenth and Fourteenth being added later.Spokane City/County Historic Preservation Office, Historic Resources Inventory: Historic Cannon's Addition (Spokane: The Office, 1992), unpaged.

In 1887 J.T. Davis and Henry Brooks opened a brickyard on South Monroe between what would later be known as Cannon Hill Park and Cannon's Addition.Lora Olson, "Cannon Hill Area Has Rich History," Spokesman Review, July 21, 1988, S-9. The site was rich in clay deposits, and the brickyard was later developed into the Washington Brick, Lime & Sewer Pipe Company. By 1900, Cannon's Addition began to experience increased growth and evolved into a middle class residential neighborhood; over the next fifteen years Spokane grew from a city of 30,000 to a population of 100,000. Once the site of the brickyard had been exhausted of its clay deposits, the company moved its operations elsewhere and by 1909 the site was being developed into residential properties and Cannon Hill Park. After 1920, construction in Cannon's Addition was minimal. The houses constructed during the development of Cannon's Addition ranged in style from the American Foursquare, Tudor Revival and Neoclassical to more modest Craftsman and bungalow style houses.

Comstock

Comstock is a mostly residential neighborhood south of 29th Avenue and west of Perry Street on the South Hill. It is a mostly residential neighborhood that was developed in phases, initially along streetcar lines, then during the postwar housing boom. It is overwhelmingly single-family residential though there are a few other areas. Manito Shopping Center at 29th and Grand is an important commercial district for the South Hill. Sacajawea Middle School and the Lewis and Clark High School sports fields are located in the center of the neighborhood.

Grandview/Thorpe