MLD-41, also known as 1-methyl-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It has about 33% of the psychoactive potency of LSD. It has been studied with regard to cross-tolerance with LSD. Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed.
Interactions
Pharmacology Pharmacodynamics MLD-41 produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and with only slightly lower potency than LSD.
Society and culture Legal status Canada MLD-41 is not a controlled substance in Canada as of 2025.
See also Substituted lysergamide MLA-74 (1-methyl-LAE) MPD-75 (1-methyl-LPD) MBL-61 (1-methyl-2-bromo-LSD)
References
External links 1-Methyl-LSD (MLD-41) - Isomer Design LSD-25 (Discusses MLD-41) - TiHKAL - Erowid LSD-25 (Discusses MLD-41) - TiHKAL - Isomer Design