Prairie Creek may refer to:
Prairie Creek, Arkansas Prairie Creek, Florida in Alachua County, FL Prairie Creek, Indiana Prairie Creek Redwoods State Park, in California Prairie Creek (California) Prairie Creek (Iowa River tributary), a stream in Iowa Prairie Creek (Brush Creek tributary), a stream in Missouri Prairie Creek (Cowskin Creek tributary), a stream in Missouri Prairie Creek (Platte River tributary), a stream in Missouri Prairie Creek (Rapid Creek), a stream in South Dakota Prairie Creek (Paluxy River tributary), a stream in Texas Prairie Creek (Chehalis River tributary), a stream in Washington Prairie Creek Township (disambiguation)