The 2010 NFL season was the 91st regular season of the National Football League (NFL) and the 45th of the Super Bowl era.

The regular season began with the NFL Kickoff game on NBC on Thursday, September 9, at the Louisiana Superdome as the New Orleans Saints, the Super Bowl XLIV champions, defeated the Minnesota Vikings.

Tom Brady, quarterback of the New England Patriots, was named NFL MVP for the 2010 season. In Super Bowl XLV, the league's championship game played at Cowboys Stadium in Arlington, Texas, the Green Bay Packers defeated the Pittsburgh Steelers 31–25 to win their fourth Super Bowl, spoiling the Steelers' chance for a seventh title. This season also marked the first full-length season in which a team with a losing record made the playoffs, when the Seattle Seahawks won the NFC West with a 7–9 record. One week later, the Seahawks dethroned the defending champion New Orleans Saints in the wild-card round, to become the first ever sub-.500 playoff team to win a postseason game.

Labor issues NFL owners voted in 2008 to opt out of their collective bargaining agreement (CBA) with the National Football League Players Association (NFLPA) as of the end of the 2010 season. (The vote was 23 in favor, 9 against; the extension measure needed 24 to pass, which would have set the CBA to expire after the 2012 season). Since a new CBA was not reached with the NFLPA, 2010 was an uncapped season, meaning that there was no salary cap or salary floor between which teams had to operate. Also, the uncapped season limited unrestricted free agency only to players with at least six years of experience, as opposed to four under a capped season. The final eight teams alive in the 2009–10 NFL playoffs (Arizona, Dallas, Minnesota and New Orleans in the NFC; and Baltimore, Indianapolis, the New York Jets and San Diego in the AFC) were restricted in the free agents they could sign.

The issue of a CBA continued into the 2011 NFL season, affecting most of the off-season.

Player movement Free agency began on March 5, 2010.

Free agency Notable players to change teams during free agency included:

Quarterbacks Derek Anderson (Cleveland to Arizona), David Carr (N.Y. Giants to San Francisco), Jake Delhomme (Carolina to Cleveland) and Matt Leinart (Arizona to Houston). Running backs Thomas Jones (N.Y. Jets to Kansas City), Chester Taylor (Minnesota to Chicago), LaDainian Tomlinson (San Diego to N.Y. Jets) and Brian Westbrook (Philadelphia to San Francisco). Wide receivers Nate Burleson (Seattle to Detroit), TJ Houshmandzadeh (Seattle to Baltimore) and Terrell Owens (Buffalo to Cincinnati). Tight ends Chris Baker (New England to Seattle), Alge Crumpler (Tennessee to New England), Brandon Manumaleuna (San Diego to Chicago) and Ben Watson (New England to Cleveland). Offensive tackles Flozell Adams (Dallas to Pittsburgh), Shawn Andrews (Philadelphia to N.Y. Giants), Cornell Green (Oakland to Buffalo) and Artis Hicks (Minnesota to Washington). Guards Alan Faneca (N.Y. Jets to Arizona), Rex Hadnot (Cleveland to Arizona) and Wade Smith (Kansas City to Houston). Defensive ends Alex Brown (Chicago to New Orleans), Aaron Kampman (Green Bay to Jacksonville), Julius Peppers (Carolina to Chicago), Jason Taylor (Miami to N.Y. Jets) and Kyle Vanden Bosch (Tennessee to Detroit). Defensive tackles Dwan Edwards (Baltimore to Buffalo), John Henderson (Jacksonville to Oakland), Ma'ake Kemoeatu (Carolina to Washington), Cory Redding (Seattle to Baltimore) and Jamal Williams (San Diego to Denver). Linebackers Karlos Dansby (Arizona to Miami), Larry Foote (Detroit to Pittsburgh), Scott Fujita (New Orleans to Cleveland), Joey Porter (Miami to Arizona) and Will Witherspoon (Philadelphia to Tennessee). Cornerbacks Phillip Buchanon (Detroit to Washington), Marlin Jackson (Indianapolis to Philadelphia), Tim Jennings (Indianapolis to Chicago), Nate Jones (Miami to Denver), Dunta Robinson (Houston to Atlanta) and Lito Sheppard (N.Y. Jets to Minnesota). Safeties Brodney Pool (Cleveland to N.Y. Jets) and Antrel Rolle (Arizona to N.Y. Giants).

Trades

The following notable trades were made during the 2010 league year:

March 5: Arizona traded WR Anquan Boldin to Baltimore in exchange for Baltimore's third- and fourth-round selections in the 2010 NFL draft; March 5: San Diego traded CB Antonio Cromartie to the N.Y. Jets in exchange for the Jets' second-round selection in 2011; March 6: N.Y. Jets traded S Kerry Rhodes to Arizona in exchange for Arizona's fourth-round selection in 2010 and seventh-round selection in 2011; March 8: Atlanta traded CB Chris Houston to Detroit in exchange for a sixth-round selection in 2010 and conditional seventh-round selection in 2011; March 14: Cleveland traded DE Kamerion Wimbley to Oakland in exchange for a third-round selection in 2010; March 14: Cleveland traded QB Brady Quinn to Denver in exchange for RB Peyton Hillis and a sixth-round selection in 2011; March 16: Seattle traded DE Darryl Tapp to Philadelphia in exchange for DE Chris Clemons and a fourth-round selection in 2010; March 17: San Diego traded QB Charlie Whitehurst to Seattle in return for a swap of second-round selections in 2010; April 2: Philadelphia traded CB Sheldon Brown and LB Chris Gocong to Cleveland in exchange for DE Alex Hall and fourth- and fifth-round selections in 2010; April 4: Philadelphia traded QB Donovan McNabb to Washington in exchange for a second-round selection in 2010 and conditional third- or fourth-round selection in 2011; April 4: Pittsburgh traded CB Bryant McFadden to Arizona in exchange for a swap of fifth and sixth-round selections in 2010; April 5: Seattle traded G Rob Sims and a seventh-round selection to Detroit in exchange for DE Robert Henderson and a fifth-round selection in 2010; April 12: Pittsburgh traded WR Santonio Holmes to N.Y. Jets in exchange for a fifth-round selection in 2010; April 14: Denver traded WR Brandon Marshall to Miami in exchange for Miami's second-round selections in 2010 and 2011; April 16: Miami traded Ted Ginn Jr. to San Francisco in exchange for a fifth-round selection; April 19: in a three-way trade, Denver traded TE Tony Scheffler to Detroit, Detroit traded LB Ernie Sims to Philadelphia, Philadelphia sent its fifth-round selection in 2010 to Denver and Denver sent its seventh-round selection to Detroit; April 20: Tampa Bay traded QB Byron Leftwich to Pittsburgh in exchange for a seventh-round selection in 2010; April 21: St. Louis traded DT Adam Carriker to Washington in exchange for fifth- and seventh-round selections;The Washington Post April 24: Washington traded QB Jason Campbell to Oakland in exchange for a fourth-round selection in 2012; April 24: Tennessee traded RB LenDale White and DE Kevin Vickerson to Seattle in exchange for a fourth-round selection and swap of sixth-round selections in 2010; April 24: Oakland traded LB Kirk Morrison to Jacksonville in exchange for a swap of fourth- and fifth-round selections; May 10: Dallas traded LB Bobby Carpenter to St. Louis in exchange for OT Alex Barron; June 21: New Orleans traded OT Jammal Brown to Washington in exchange for a swap of third- and fourth-round selections in 2010; August 31: Seattle traded CB Josh Wilson to Baltimore for a conditional third- or fourth-round selections in 2011; September 4: Denver traded CB Alphonso Smith to Detroit in exchange for TE Dan Gronkowski; September 15: New England traded RB Laurence Maroney and a sixth-round selection in 2011 to Denver in exchange for a fourth-round selection; October 5: Buffalo traded RB Marshawn Lynch to Seattle in exchange for a fourth-round selection in 2011 and a conditional pick in 2012; October 6: New England traded WR Randy Moss and a seventh-round selection in 2012 to Minnesota in exchange for a third-round selection in 2011 and a seventh-round selection in 2012; October 11: Seattle traded WR Deion Branch to New England in exchange for a fourth-round selection in 2011; October 19: Kansas City traded DE Alex Magee to Tampa Bay in exchange for a fifth-round selection in 2011.

Draft

The league's 75th annual selection meeting, more commonly known as the NFL draft, took place at Radio City Music Hall in New York City from April 22–24, the first time that the draft was held over three days instead of the usual two. In the draft with the first overall pick, the St. Louis Rams chose quarterback Sam Bradford from the University of Oklahoma.

Officiating changes Mike Pereira resigned as the league's Vice President of Officiating. He had led the NFL's officiating since 2001. Carl Johnson was named as Pereira's successor.

Clete Blakeman was promoted to referee, and Don Carey returned to his back judge position.

Rule changes The following rule changes were passed at the league's annual owners meeting in March: The overtime procedure for postseason games was changed. Instead of a straight sudden death period in which the first team to score by any method wins, the game will not immediately end if the team that receives the ball first scores a field goal on its first possession (the game will still end if they score a touchdown or if the defense scores a touchdown or safety). Instead, the other team gets a possession. If the second team on offense then scores a touchdown, it is declared the winner. If the score is tied after both teams had a possession, the rest of the overtime is played under sudden death. These changes were passed in response to recent statistics which showed that since 1994, teams that won the overtime period coin toss won 59.8 percent of the time, and won 34.4 percent of the time on the first possession on a field goal. In May, the league decided against applying these overtime rule changes to regular season games as well, although this was adopted two years later. The definition of a "defenseless receiver" (in which a receiver cannot be hit in the head or neck area by an opponent who launches himself and makes contact with his helmet, shoulder, or forearm) will now apply to every defenseless player. A play will now immediately be whistled dead if a ball carrier's helmet is removed. The position of the umpire has been moved from behind the defensive linebackers (except in the last two minutes of the first half, the last five minutes of the second half/overtime, and anytime the offense is inside the defense's five-yard-line) to the offensive backfield opposite the throwing arm of the quarterback in order to reduce the numerous times that the official has been run over during plays. During field goal and extra point attempts, defenders cannot line up directly across from the long snapper. Dead ball 15-yard personal fouls that are committed on the final play of either the second or fourth quarters will be assessed on the second half or overtime kickoff, respectively. Previously, such penalties during those situations were not enforced. Punt returners who make a fair catch signal but then muff the ball are entitled the opportunity to catch the ball before it hits the ground without interference. If there is interference during such a scenario, the receiving team is awarded the ball at the spot of the foul, but no penalty yardage is assessed. The 2009 temporary modification to the rules regarding balls in play that strike an object such as a video board or a guide wire has been made permanent. Prior to 2009, only the down was replayed. The 2009 modification added resetting the game clock to the time when the original play was snapped. The replay system will now also be allowed to cover whether there was some sort of interference with the ball during a play.