William McGuire may refer to:
William Anthony McGuire (1881–1940), American screenwriter and dramatist William Henry McGuire (1875–1957), Canadian senator William J. McGuire, American social psychologist William W. McGuire (contemporary, born 1948), American physician; former CEO of UnitedHealth Group Billy and Benny McGuire, "World's Heaviest Twins" William McGuire (footballer) (fl. 1881), Scottish international football player William McGuire (judge), one of the three first judges of the Mississippi Territory William T. "Bill" McGuire, a man murdered by his wife in 2004
See also Bill McGuire (disambiguation)